Event Details
Computational Biomechanics: From Molecules to Organs
Presenter: Prof. C. Ross Ethier - Canada Research Chair in Computational Technology, Department of Mechanical and Industrial Engineering, University of Toronto
Supervisor:
Date: Wed, July 16, 2003
Time: 15:30:00 - 00:00:00
Place: EOW 430
ABSTRACT
Abstract:
Cells and tissues respond to imposed mechanical stimuli. For example, chondrocytes alter their biosynthetic output in response to imposed cyclic deformations, vascular endothelial cells alter their permeability in response to shear stress and cyclic stretch, etc. Biomechanics is the study of how biological systems respond to imposed mechanical stimulation. Computational biomechanics studies this field using computational methodologies, primarily by simulation.
In this talk I will give an overview of the field by presenting examples from four specific areas of application covering length scales from the molecular to the whole organ: molecular modelling of titin extension in muscle, modelling of subcellular mass transfer to endothelium, modelling of blood flow patterns in the right coronary artery, and modelling of optic nerve head biomechanics in glaucoma.